Weight Loss Injections Explained: Why They Work, and When They Don't
Social media is filled with people using weight loss injections at the minute. Glucagon-like peptide-1 (GLP-1) agonists, originally formulated to treat diabetes, are now being widely used to slim down. With many celebrities and influencers rumoured to be taking the treatment, we’re left asking: how do these injections promote weight loss, and are they safe?
Do Weight Loss Injections Really Work?
Weight loss injections typically contain a compound that mimics GLP-1, which is a gut hormone naturally produced by the body.
GLP-1 delays the emptying of the stomach following digestion, and acts within the brain, overall suppressing hunger and food cravings, and promoting feelings of fullness. This explains why weight loss injections often cause people to consume less food, resulting in weight loss (1). Their effectiveness has been shown through a number of clinical trials, with patients losing an average of 7.1kg across the trial period (2). It is evident that, when combined with a healthy diet and exercise regime, these injections are powerful agents for reducing obesity.
When Are They Less Effective?
There are a few reasons why weight loss injections may not be effective for everyone.
The most important factor is to maintain a healthy diet and exercise regularly. While less likely, it is still possible to overeat during treatment, negating the effects of appetite suppression. Moreover, this method of weight loss is not specifically for fat loss, so exercise is crucial to maintain muscle mass and prevent sarcopenia (loss of muscle and bone density) (3).
The injections also may not be as effective if they are not taken often or long enough. With the high cost of injections, it can be difficult to afford a supply over a long period of time, which is something to be considered before initiating treatment.
As with every treatment, results can vary between individuals for many reasons, so it is important to seek a specialist opinion before beginning treatment.
What Are The Potential Side Effects?
Another factor that can prevent people adhering to treatment plan is the experience of negative side effects. Patients commonly experience gastrointestinal side effects such as nausea, vomiting and bowel issues. While typically non-serious, these can be debilitating and even lead to hospitalisation.
Is it worth taking injections to lose weight if quality of life does not improve?
In summary, GLP-1-like injections can be used to effectively lose weight by reducing gastric emptying and suppressing appetite. This treatment works best with healthy eating and regular exercise. People seeking weight loss injections should remain wary of the factors that may make treatment ineffective, and consult a medical professional to check the safety of the treatment based on their current health. More research into the long-term effects of weight loss injection is required to ensure safe use, minimising negative side effects.
Disclaimer:
The information shared in this article is for general educational purposes and should not be considered medical advice. We mention weight loss injections as part of the discussion, but we do not endorse any specific product or brand. Results can vary depending on individual health, lifestyle, and other factors, so it’s important to consult your healthcare provider before considering any treatment. Always prioritise your health and well-being by seeking personalised advice from your healthcare expert.
References:
(1) Ard, J., Fitch, A., Fruh, S. and Herman, L. (2021) Weight Loss and Maintenance Related to the Mechanism of Action of Glucagon-like Peptide 1 Receptor Agonists. Advances in Therapy, 38(6), pp.2821-2839. doi:https://doi.org/10.1007/s12325-021-01710-0.
(2) Iqbal, J., Wu, H., Hu, N., Zhou, Y., Li, L., Xiao, F., Wang, T., Jiang, H., Xu, S., Huang, B. and Zhou, H. (2022) Effect of glucagon-like peptide-1 receptor agonists on body weight in adults with obesity without diabetes mellitus – a systematic review and meta-analysis of randomized control trials. Obesity Reviews, 23(6). doi://https://doi.org/10.1111.obr.13435
(3) Heathline. (2023). Ozempic May Make Your Muscles and Bones Weaker [online] Available at: https://www.healthline.com/health-news/ozempic-muscle-mass-loss
(4) GOV.UK (2024. GLP-1 receptor agonists: reminder of the potential side effects and to be aware of the potential for misuse. [online] Available at: https://www.gov.uk/drug-safety-update/glp-1-receptor-agonists-reminder-of-the-potential-side-effects-and-to-be-aware-of-the-potential-for-misuse
