Ingredient Spotlight: Minoxidil for Hair Loss
What is Minoxidil?
Originally developed as an oral medication to treat high blood pressure, Minoxidil gained unexpected fame when patients noticed a surprising side effect: hair regrowth. Today, it is widely used as both oral medication and topical treatment for male and female pattern baldness.
How Does Minoxidil Work to Promote Hair Growth?
Minoxidil is a vasodilator which stimulates hair growth by improving blood flow to hair follicles, delivering essential oxygen and nutrients that support healthy hair [1]. It also prolongs the anagen phase - the active growth stage of the hair cycle - allowing hair to grow thicker and longer. Research suggests that Minoxidil works by opening potassium channels in follicular cells, which enhances follicle activity and regrowth [2]. Combining frequent scalp massages to promote blood flow and Minoxidil has shown to enhance its effects [3]. However, common side effects include scalp irritation, dryness, and in rare cases, unwanted facial hair growth when misapplied.
Clinical Evidence of Minoxidil
Clinical research strongly supports Minoxidil’s efficacy in treating hair loss. A 48-week study involving 393 participants using a 5% Minoxidil solution revealed significant improvements in hair regrowth compared to a placebo [4]. Females are usually advised to use the 2% Minoxidil solution, however the 5% Minoxidil is much more effective. Another study showed sustained increases in hair density over 12 months, cementing its reputation as a reliable long-term solution for hair regrowth [5].
Rosemary Oil or Minoxidil?
You may have read our recent blog on Rosemary Oil, so let’s compare.
While Minoxidil boasts extensive clinical backing, rosemary oil is gaining attention as a natural alternative. Rosemary oil is gentle on the scalp and may help stimulate hair growth, but research remains limited. Minoxidil, with its proven results and established safety profile, is the more dependable option for those seeking consistent regrowth.
Rojin’s Experience with Minoxidil
I started using Minoxidil in August 2024 after noticing thinning in my hair part, hoping it would help address my androgenic alopecia and restore my confidence. I use minoxidil daily and within three months, I noticed baby hairs filling the sparse areas! Initially, dryness and irritation were challenging, but incorporating a scalp shampoo such as the Nizoral Ketoconazole shampoo helped. If you’re someone who has noticed hair thinning and/or wants to grow their hair, Minoxidil is a great option.
My advice? Be patient and consistent as a sudden stop in using Minoxidil may do the reverse effect. Results take time, but the payoff is definitely worth the wait.
Disclaimer:
The information provided in this article is for educational purposes only. Results from using Minoxidil can vary from person to person, and it’s important to consult your healthcare professional before starting any new treatment. Individual needs and responses may differ.
References:
1. 1.Kozicka K, Łukasik A, Pastuszczak M, Dyduch G, Kłosowicz A, Wojas-Pelc A. Scalp vascularization as a marker of topical minoxidil treatment efficacy in patients with androgenetic alopecia. Advances in Dermatology and Allergology. 2021;
2. Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. Minoxidil Use in Dermatology, Side Effects and Recent Patents. Recent Patents on Inflammation & Allergy Drug Discovery. 2012 Apr 1;6(2):130–6.
3. 1.Hims [Internet]. Hims. 2017 [cited 2024 Dec 2]. Available from: https://www.forhims.co.uk/blog/massaging-scalp-help-hair-growth?srsltid=AfmBOoq7a 7Gkp95xHGDtYIU6xN4sg4JDoBPOW4RjFOgwAqmo_YQd747q
4. Olsen EA, Dunlap FE, Funicella T, Koperski JA, Swinehart JM, Tschen EH, et al. A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. Journal of the American Academy of Dermatology. 2002 Sep;47(3):377–85.
5. Suchonwanit P, Thammarucha S, Leerunyakul K. Minoxidil and its use in hair disorders: a review. Drug Design, Development and Therapy. 2019 Aug;Volume 13:2777–86.